Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation
نویسندگان
چکیده
منابع مشابه
Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation
OBJECTIVES The endothelium maintains vascular homeostasis through the release of endothelium-derived relaxing factors (EDRF) and endothelium-derived hyperpolarization (EDH). The balance in EDH : EDRF is disturbed in cardiovascular disease and may also be susceptible to developmental conditioning through exposure to an adverse uterine environment to predispose to later risk of hypertension and v...
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The endothelium plays an important role in maintaining the vascular homeostasis by releasing vasodilator substances, including prostacyclin (PGI2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). Although the former two substances have been investigated extensively, the importance of EDHF still remains unclear, especially in human arteries. Thus we tested our hypothesi...
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ژورنال
عنوان ژورنال: Journal of Hypertension
سال: 2016
ISSN: 0263-6352
DOI: 10.1097/hjh.0000000000000833